Dedicator of cytokinesis protein 8

DOCK8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VHL
Identifiers
Aliases	DOCK8, HEL-205, MRD2, ZIR8, Dock8, dedicator of cytokinesis 8
External IDs	OMIM: 611432; MGI: 1921396; HomoloGene: 52414; GeneCards: DOCK8; OMA:DOCK8 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	465,259 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	25,179,796 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; white blood cell; ; monocyte; ; thymus; ; blood; ; spleen; ; granulocyte; ; lymph node; ; appendix; ; pancreatic ductal cell;
	Top expressed in
	granulocyte; ; thymus; ; spleen; ; tibiofemoral joint; ; mesenteric lymph nodes; ; transitional epithelium of urinary bladder; ; bone marrow; ; blood; ; olfactory epithelium; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytosol; cell leading edge; leading edge membrane; cytoplasm; plasma membrane; membrane; lamellipodium membrane; cell projection; intracellular anatomical structure;
Biological process	negative regulation of T cell apoptotic process; small GTPase mediated signal transduction; immunological synapse formation; blood coagulation; memory T cell proliferation; dendritic cell migration; positive regulation of GTPase activity; positive regulation of establishment of T cell polarity; cellular response to chemokine; positive regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologs
	81704
	76088
	ENSG00000107099
	ENSMUSG00000052085
	Q8NF50
	Q8C147
	NM_001190458; NM_001193536; NM_203447
	NM_028785; NM_175233
	NP_001177387; NP_001180465; NP_982272; NP_001180465.1
	NP_083061
	Wikidata
View/Edit Human	View/Edit Mouse

Dedicator of cytokinesis protein 8 (Dock8) is a large (~190 kDa) protein encoded in the human by the DOCK8 gene, involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G-proteins.