Dedicator of cytokinesis protein 9

DOCK9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WG7, 2WM9, 2WMN, 2WMO
Identifiers
Aliases	DOCK9, ZIZ1, ZIZIMIN1, Dock9, dedicator of cytokinesis 9
External IDs	OMIM: 607325; MGI: 106321; HomoloGene: 41026; GeneCards: DOCK9; OMA:DOCK9 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	99,086,625 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	122,035,249 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; right lung; ; corpus callosum; ; Region I of hippocampus proper; ; lower lobe of lung; ; oral cavity; ; sural nerve; ; skin of hip; ; inferior olivary nucleus; ; upper lobe of lung;
	Top expressed in
	subiculum; ; right lung lobe; ; sciatic nerve; ; CA3 field; ; cerebellar vermis; ; Region I of hippocampus proper; ; lobe of cerebellum; ; tunica adventitia of aorta; ; deep cerebellar nuclei; ; endothelial cell of lymphatic vessel;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; guanyl-nucleotide exchange factor activity; cadherin binding;
Cellular component	cytosol; endomembrane system; membrane;
Biological process	blood coagulation; small GTPase mediated signal transduction; positive regulation of GTPase activity; biological process;
	Sources:Amigo / QuickGO
Orthologs
	23348
	105445
	ENSG00000088387
	ENSMUSG00000025558
	Q9BZ29
	Q8BIK4
NM_001130048; NM_001130049; NM_001130050; NM_015296; NM_001318849;
	NM_001366676; NM_001366677; NM_001366678; NM_001366679; NM_001366680; NM_001366681; NM_001366682; NM_001366683; NM_001366684
	NM_001081039; NM_001128307; NM_001128308; NM_134074; NM_001347596
NP_001123520; NP_001123521; NP_001123522; NP_001305778; NP_056111;
	NP_001353605; NP_001353606; NP_001353607; NP_001353608; NP_001353609; NP_001353610; NP_001353611; NP_001353612; NP_001353613
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Dedicator of cytokinesis protein 9 (Dock9), also known as Zizimin1, is a large (~230 kDa) protein encoded in the human by the DOCK9 gene, involved in intracellular signalling networks. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors that function as activators of small G-proteins. Dock9 activates the small G protein Cdc42.