| DOLK |
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| Identifiers |
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| Aliases | DOLK, CDG1M, DK, DK1, SEC59, TMEM15, dolichol kinase |
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| External IDs | OMIM: 610746; MGI: 2677836; HomoloGene: 8940; GeneCards: DOLK; OMA:DOLK - orthologs |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 2 (mouse) |
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| | Band | 2|2 B | Start | 30,174,243 bp |
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| End | 30,176,346 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - gonad
- stromal cell of endometrium
- right adrenal cortex
- left adrenal gland
- left adrenal cortex
- islet of Langerhans
- testicle
- gingival epithelium
- parotid gland
- nasal epithelium
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| | Top expressed in | - interventricular septum
- brown adipose tissue
- external carotid artery
- internal carotid artery
- tunica adventitia of aorta
- white adipose tissue
- vastus lateralis muscle
- intercostal muscle
- subcutaneous adipose tissue
- motor neuron
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| | More reference expression data |
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| BioGPS | |
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| Wikidata |
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In enzymology, a dolichol kinase (EC 2.7.1.108) is an enzyme that catalyzes the chemical reaction
- CTP + dolichol
CDP + dolichyl phosphate
Thus, the two substrates of this enzyme are CTP and dolichol, whereas its two products are CDP and dolichyl phosphate.
This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is CTP:dolichol O-phosphotransferase. This enzyme is also called dolichol phosphokinase. This enzyme participates in N-glycan biosynthesis.
In humans dolichol kinase is encoded by the DOLK gene.
