DOP1B

DOP1B
Identifiers
Aliases	DOP1B, 21orf5, C21orf5, dopey family member 2, DOPEY2, DOP1 leucine zipper like protein B
External IDs	OMIM: 604803; MGI: 1917278; HomoloGene: 21068; GeneCards: DOP1B; OMA:DOP1B - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	36,294,274 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	93,607,478 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; rectum; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; monocyte; ; testicle; ; minor salivary glands; ; muscle of leg; ; gastrocnemius muscle;
	Top expressed in
	granulocyte; ; epithelium of stomach; ; superior frontal gyrus; ; primary visual cortex; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; duodenum; ; secondary oocyte; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	molecular function;
Cellular component	Golgi membrane; extracellular exosome; cytosol; endosome; trans-Golgi network; Golgi apparatus; membrane;
Biological process	multicellular organism development; protein transport; cognition; endoplasmic reticulum organization; Golgi to endosome transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	9980
	70028
	ENSG00000142197
	ENSMUSG00000022946
	Q9Y3R5
	Q3UHQ6
	NM_005128; NM_001320714
	NM_026700; NM_027293; NM_001357118
	NP_001307643; NP_005119
	NP_080976; NP_081569; NP_001344047
	Wikidata
View/Edit Human	View/Edit Mouse

DOP1B is a human gene located just above the Down Syndrome chromosomal region (DSCR) located at 21p22.2 sub-band. Although the exact function of this gene is not yet fully understood, it has been proven to play a role in multiple biological processes, and its over-expression (triplication) has been linked to multiple facets of the Down Syndrome phenotype, most notably mental retardation.