2,5-Dimethoxy-4-tert-butylamphetamine

2,5-Dimethoxy-4-tert-butylamphetamine
Clinical data
Other names2,5-Dimethoxy-4-tert-butylamphetamine; DOTB; DOtBu; 4-tert-Butyl-2,5-dimethoxyamphetamine
Routes of
administration
Oral
Drug classSerotonin receptor modulator; Serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor modulator
Identifiers
  • 1-(4-tert-butyl-2,5-dimethoxyphenyl)propan-2-amine
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H25NO2
Molar mass251.370 g·mol−1
3D model (JSmol)
  • CC(CC1=CC(=C(C=C1OC)C(C)(C)C)OC)N
  • InChI=1S/C15H25NO2/c1-10(16)7-11-8-14(18-6)12(15(2,3)4)9-13(11)17-5/h8-10H,7,16H2,1-6H3
  • Key:RUAUPNFNQOGIFF-UHFFFAOYSA-N

2,5-Dimethoxy-4-tert-butylamphetamine (DOTB or DOtBu) is a non-hallucinogenic serotonin receptor modulator of the phenethylamine, amphetamine, and DOx families.