Dipeptidase 1

DPEP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ITQ, 1ITU
Identifiers
Aliases	DPEP1, MBD1, MDP, RDP, dipeptidase 1 (renal), dipeptidase 1
External IDs	OMIM: 179780; MGI: 94917; HomoloGene: 80192; GeneCards: DPEP1; OMA:DPEP1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	89,638,456 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,928,551 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; body of pancreas; ; human kidney; ; kidney tubule; ; left testis; ; right testis; ; duodenum; ; jejunal mucosa; ; glomerulus; ; metanephric glomerulus;
	Top expressed in
	tunica adventitia of aorta; ; ascending aorta; ; jejunum; ; right kidney; ; gastrula; ; aortic valve; ; human kidney; ; tunica media of zone of aorta; ; carotid body; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metallodipeptidase activity; zinc ion binding; metal ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; peptidase activity; GPI anchor binding; modified amino acid binding; protein binding; metalloexopeptidase activity; hydrolase activity; metallopeptidase activity; dipeptidyl-peptidase activity; dipeptidase activity;
Cellular component	cell projection; membrane; plasma membrane; apical part of cell; apical plasma membrane; anchored component of membrane; extracellular exosome; microvillus membrane; extracellular space; nucleus; cell junction;
Biological process	cellular response to calcium ion; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; leukotriene metabolic process; glutathione metabolic process; antibiotic metabolic process; negative regulation of apoptotic process; proteolysis; negative regulation of cell migration; xenobiotic metabolic process; cellular response to nitric oxide; homocysteine metabolic process; cellular lactam catabolic process; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	1800
	13479
	ENSG00000015413
	ENSMUSG00000019278
	P16444
	P31428
	NM_001128141; NM_004413
	NM_007876
	NP_001121613; NP_004404
	NP_031902
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidase 1 (DPEP1), or renal dipeptidase, is a membrane-bound glycoprotein responsible for hydrolyzing dipeptides. It is found in the microsomal fraction of the porcine kidney cortex. It exists as a disulfide-linked homodimer that is glygosylphosphatidylinositol (GPI)-anchored to the renal brush border of the kidney. The active site on each homodimer is made up of a barrel subunit with binuclear zinc ions that are bridged by the Gly125 side-chain located at the bottom of the barrel.