Dipeptidyl peptidase-4

DPP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J2E, 1N1M, 1NU6, 1NU8, 1PFQ, 1R9M, 1R9N, 1RWQ, 1TK3, 1TKR, 1U8E, 1W1I, 1WCY, 1X70, 2AJL, 2BGN, 2BGR, 2BUB, 2FJP, 2G5P, 2G5T, 2G63, 2HHA, 2I03, 2I78, 2IIT, 2IIV, 2JID, 2OAG, 2OGZ, 2OLE, 2ONC, 2OPH, 2OQI, 2OQV, 2P8S, 2QJR, 2QKY, 2QOE, 2QT9, 2QTB, 2RGU, 2RIP, 3BJM, 3C43, 3C45, 3CCB, 3CCC, 3D4L, 3EIO, 3F8S, 3G0B, 3G0C, 3G0D, 3G0G, 3H0C, 3HAB, 3HAC, 3KWF, 3KWJ, 3NOX, 3O95, 3O9V, 3OC0, 3OPM, 3Q0T, 3Q8W, 3QBJ, 3SWW, 3SX4, 3VJK, 3VJL, 3VJM, 3W2T, 4A5S, 4DSA, 4DSZ, 4DTC, 4G1F, 4JH0, 4KR0, 4L72, 4LKO, 4J3J, 4N8D, 4N8E, 4PNZ, 4PV7, 4QZV, 3WQH, 5KBY, 5ISM, 5I7U
Identifiers
Aliases	DPP4, ADABP, ADCP2, CD26, DPPIV, TP103, dipeptidyl peptidase 4
External IDs	OMIM: 102720; MGI: 94919; HomoloGene: 3279; GeneCards: DPP4; OMA:DPP4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	162,074,215 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	62,242,575 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; jejunal mucosa; ; parotid gland; ; tendon of biceps brachii; ; duodenum; ; kidney tubule; ; placenta; ; stromal cell of endometrium; ; parietal pleura; ; seminal vesicula;
	Top expressed in
	jejunum; ; vestibular membrane of cochlear duct; ; seminal vesicula; ; saccule; ; ileum; ; lacrimal gland; ; parotid gland; ; left lobe of liver; ; renal corpuscle; ; migratory enteric neural crest cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	dipeptidyl-peptidase activity; signaling receptor binding; identical protein binding; peptidase activity; hydrolase activity; virus receptor activity; protein homodimerization activity; serine-type peptidase activity; protease binding; aminopeptidase activity; protein binding; serine-type endopeptidase activity;
Cellular component	lamellipodium membrane; extracellular exosome; lysosomal membrane; endocytic vesicle; integral component of membrane; cell projection; cell junction; lamellipodium; apical plasma membrane; membrane; focal adhesion; cell surface; intercellular canaliculus; membrane raft; extracellular region; plasma membrane;
Biological process	response to hypoxia; T cell costimulation; psychomotor behavior; behavioral fear response; negative regulation of extracellular matrix disassembly; regulation of cell-cell adhesion mediated by integrin; locomotory exploration behavior; endothelial cell migration; positive regulation of cell population proliferation; T cell activation; cell adhesion; viral entry into host cell; regulation of insulin secretion; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	1803
	13482
	ENSG00000197635
	ENSMUSG00000035000
	P27487
	P28843
	NM_001935
	NM_001159543; NM_010074
	NP_001926; NP_001366533; NP_001366534; NP_001366535
	NP_001153015; NP_034204
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidyl peptidase-4 (DPP4 or DPPIV), also known as adenosine deaminase complexing protein 2 or CD26 (cluster of differentiation 26) is a protein that, in humans, is encoded by the DPP4 gene. DPP4 is related to FAP, DPP8, and DPP9. The enzyme was discovered in 1966 by Hopsu-Havu and Glenner, and as a result of various studies on chemism, was called dipeptidyl peptidase IV [DP IV].