Dihydropyrimidine dehydrogenase (NADP+)
| dihydropyrimidine dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Dihydroprymidine dehydrogenase dimer, Sus scrofa | |||||||||
| Identifiers | |||||||||
| EC no. | 1.3.1.2 | ||||||||
| CAS no. | 9029-01-0 | ||||||||
| Alt. names | Dihydrothymine dehydrogenase | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a dihydropyrimidine dehydrogenase (NADP+) (EC 1.3.1.2) is an enzyme that catalyzes the chemical reaction
- 5,6-dihydrouracil + NADP+ uracil + NADPH + H+
Thus, the two substrates of this enzyme are 5,6-dihydrouracil and NADP+, whereas its 3 products are uracil, NADPH, and H+.
In humans the enzyme is encoded by the DPYD gene. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and tegafur. It also participates in beta-alanine metabolism and pantothenate and coa biosynthesis.