DPYS

DPYS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VR2
Identifiers
Aliases	DPYS, dihydropyrimidinase, DHP, DHPase
External IDs	OMIM: 613326; MGI: 1928679; HomoloGene: 20359; GeneCards: DPYS; OMA:DPYS - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	104,467,055 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	39,720,866 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; right adrenal cortex; ; left adrenal cortex; ; testicle; ; gonad; ; mucosa of paranasal sinus;
	Top expressed in
	left lobe of liver; ; primary oocyte; ; proximal tubule; ; right kidney; ; respiratory epithelium; ; olfactory epithelium; ; zygote; ; secondary oocyte; ; embryo; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	amino acid binding; zinc ion binding; metal ion binding; dihydropyrimidinase activity; phosphoprotein binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; thymine binding; uracil binding; hydrolase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	beta-alanine metabolic process; uracil catabolic process; pyrimidine nucleoside catabolic process; uracil metabolic process; pyrimidine nucleobase catabolic process; protein homooligomerization; protein homotetramerization; thymine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1807
	64705
	ENSG00000147647
	ENSMUSG00000022304
	Q14117
	Q9EQF5
	NM_001385
	NM_001164466; NM_022722
	NP_001376
	NP_001157938; NP_073559
	Wikidata
View/Edit Human	View/Edit Mouse

Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.