Dysbindin

DTNBP1
Identifiers
Aliases	DTNBP1, BLOC1S8, DBND, HPS7, My031, SDY, dystrobrevin binding protein 1
External IDs	OMIM: 607145; MGI: 2137586; HomoloGene: 12037; GeneCards: DTNBP1; OMA:DTNBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	15,663,058 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	45,155,623 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; nucleus accumbens; ; putamen; ; internal globus pallidus; ; caudate nucleus; ; Hypothalamus; ; Amygdala; ; cingulate gyrus; ; anterior cingulate cortex; ; substantia nigra;
	Top expressed in
	interventricular septum; ; right kidney; ; spermatocyte; ; yolk sac; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; brown adipose tissue; ; muscle of thigh; ; visual cortex; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; endosome; postsynaptic membrane; endoplasmic reticulum membrane; membrane; postsynaptic density; growth cone; BLOC-1 complex; plasma membrane; dendritic spine; synapse; synaptic vesicle membrane; melanosome membrane; axon; cell junction; endoplasmic reticulum; sarcoplasm; neuron projection; sarcolemma; endosome membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; nucleus; axon cytoplasm; microtubule cytoskeleton; midbody; asymmetric synapse; Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse;
Biological process	actin cytoskeleton reorganization; regulation of dopamine secretion; neuron projection morphogenesis; platelet dense granule organization; response to stimulus; regulation of dopamine receptor signaling pathway; positive regulation of neurotransmitter secretion; blood coagulation; organelle organization; anterograde axonal transport; melanosome organization; positive regulation of gene expression; anterograde synaptic vesicle transport; neuron projection development; regulation of JUN kinase activity; negative regulation of protein serine/threonine kinase activity; dendrite morphogenesis; negative regulation of protein binding; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	84062
	94245
	ENSG00000047579
	ENSMUSG00000057531
	Q96EV8
	Q91WZ8
	NM_001271667; NM_001271668; NM_001271669; NM_032122; NM_183040
	NM_025772
	NP_001258596; NP_001258597; NP_001258598; NP_115498; NP_898861
	NP_080048
	Wikidata
View/Edit Human	View/Edit Mouse

Dysbindin, short for dystrobrevin-binding protein 1, is a protein constituent of the dystrophin-associated protein complex (DPC) of skeletal muscle cells. It is also a part of BLOC-1, or biogenesis of lysosome-related organelles complex 1.In humans, dysbindin is encoded by the DTNBP1 gene.