Dual oxidase 1

DUOX1
Identifiers
Aliases	DUOX1, LNOX1, NOXEF1, THOX1, dual oxidase 1
External IDs	OMIM: 606758; MGI: 2139422; HomoloGene: 68136; GeneCards: DUOX1; OMA:DUOX1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	45,165,576 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	122,178,453 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right lung; ; bronchial epithelial cell; ; gums; ; gingival epithelium; ; right uterine tube; ; skin of abdomen; ; skin of leg; ; lower lobe of lung;
	Top expressed in
	esophagus; ; lip; ; conjunctival fornix; ; transitional epithelium of urinary bladder; ; skin of external ear; ; knee joint; ; lumbar subsegment of spinal cord; ; cornea; ; embryo; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; peroxidase activity; metal ion binding; heme binding; NADP binding; oxidoreductase activity; NAD(P)H oxidase H2O2-forming activity; protein binding; superoxide-generating NAD(P)H oxidase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; apical plasma membrane; endoplasmic reticulum; cell surface; cell leading edge; NADPH oxidase complex;
Biological process	cuticle development; cytokine-mediated signaling pathway; cellular oxidant detoxification; response to oxidative stress; reactive oxygen species metabolic process; superoxide anion generation; thyroid hormone generation; hydrogen peroxide catabolic process; hydrogen peroxide biosynthetic process; response to cAMP; hormone biosynthetic process; positive regulation of wound healing; positive regulation of cell motility; defense response;
	Sources:Amigo / QuickGO
Orthologs
	53905
	99439
	ENSG00000137857
	ENSMUSG00000033268
	Q9NRD9
	A2AQ92
	NM_017434; NM_175940
	NM_001099297
	NP_059130; NP_787954
	NP_001092767
	Wikidata
View/Edit Human	View/Edit Mouse

Dual oxidase 1, also known as DUOX1 or ThOX1 (for thyroid oxidase), is an enzyme which in humans is encoded by the DUOX1 gene. DUOX1 was first identified in the mammalian thyroid gland. In humans, two isoforms are found; hDUOX1 and hDUOX2. Human DUOX protein localization is not exclusive to thyroid tissue; hDUOX1 is prominent in airway epithelial cells and hDUOX2 in the salivary glands and gastrointestinal tract.