DUSP1

DUSP1
Identifiers
Aliases	DUSP1, CL100, HVH1, MKP-1, MKP1, PTPN10, dual specificity phosphatase 1
External IDs	OMIM: 600714; MGI: 105120; HomoloGene: 3254; GeneCards: DUSP1; OMA:DUSP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	172,771,195 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,781,102 bp
RNA expression pattern
	Top expressed in
	vena cava; ; nipple; ; urethra; ; mucosa of paranasal sinus; ; skin of thigh; ; mucosa of urinary bladder; ; cardia; ; lower lobe of lung; ; saphenous vein; ; trachea;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; endothelial cell of lymphatic vessel; ; right lung; ; right lung lobe; ; plantaris muscle; ; ascending aorta; ; soleus muscle; ; ankle; ; left lobe of liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein tyrosine/threonine phosphatase activity; phosphatase activity; protein tyrosine phosphatase activity; protein binding; phosphoprotein phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; growth factor binding; protein serine/threonine phosphatase activity; mitogen-activated protein kinase binding;
Cellular component	nucleus; cytoplasm;
Biological process	positive regulation of apoptotic process; response to estradiol; response to retinoic acid; response to oxidative stress; negative regulation of meiotic cell cycle; response to calcium ion; response to hydrogen peroxide; response to testosterone; protein dephosphorylation; intracellular signal transduction; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; peptidyl-threonine dephosphorylation; cell cycle; response to light stimulus; negative regulation of DNA biosynthetic process; negative regulation of ERK1 and ERK2 cascade; cellular response to hormone stimulus; dephosphorylation; regulation of apoptotic process; response to glucocorticoid; endoderm formation; response to organic substance; regulation of mitotic cell cycle spindle assembly checkpoint; negative regulation of apoptotic process; response to cAMP; negative regulation of cell population proliferation; peptidyl-tyrosine dephosphorylation; peptidyl-serine dephosphorylation; negative regulation of cell adhesion; negative regulation of monocyte chemotaxis; negative regulation of p38MAPK cascade; cellular response to chemokine;
	Sources:Amigo / QuickGO
Orthologs
	1843
	19252
	ENSG00000120129
	ENSMUSG00000024190
	P28562
	P28563
	NM_004417
	NM_013642
	NP_004408
	NP_038670
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.