DUX4

DUX4
Identifiers
Aliases	DUX4, DUX4L, double homeobox 4
External IDs	OMIM: 606009; GeneCards: DUX4; OMA:DUX4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	190,185,942 bp
RNA expression pattern
	Top expressed in
	gonad; ; monocyte; ; sural nerve; ; left testis; ; muscle of thigh; ; right testis; ; primary visual cortex; ; smooth muscle tissue; ; duodenum; ; apex of heart;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; transcription cis-regulatory region binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific double-stranded DNA binding;
Cellular component	nuclear membrane; nucleus; nucleoplasm; nucleolus; cytosol; Golgi apparatus;
Biological process	negative regulation of G0 to G1 transition; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; apoptotic process; transcription by RNA polymerase II; multicellular organism development;
	Sources:Amigo / QuickGO
Orthologs
	100288687
	n/a
	ENSG00000260596; ENSG00000283949
	n/a
	Q9UBX2
	n/a
	NM_001205218; NM_001278056; NM_001293798; NM_001306068; NM_001363820
	n/a
	NP_001280727; NP_001292997; NP_001350749
	n/a
	Wikidata
View/Edit Human

Double homeobox, 4 also known as DUX4 is a protein which in humans is encoded by the DUX4 gene. Its misexpression is the cause of facioscapulohumeral muscular dystrophy (FSHD).