DVL1

DVL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FSH, 1MC7, 2KAW, 3PZ8
Identifiers
Aliases	DVL1, DVL, DVL1L1, DVL1P1, DRS2, dishevelled segment polarity protein 1
External IDs	OMIM: 601365; MGI: 94941; HomoloGene: 20926; GeneCards: DVL1; OMA:DVL1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,349,418 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,943,760 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; apex of heart; ; right frontal lobe; ; pancreatic ductal cell; ; body of tongue; ; thoracic diaphragm; ; Amygdala; ; right hemisphere of cerebellum;
	Top expressed in
	medullary collecting duct; ; Paneth cell; ; renal corpuscle; ; substantia nigra; ; barrel cortex; ; Rostral migratory stream; ; motor neuron; ; vastus lateralis muscle; ; ascending aorta; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	beta-catenin binding; frizzled binding; protein binding; identical protein binding; enzyme binding; protein kinase binding;
Cellular component	cytoplasm; cytosol; Wnt signalosome; lateral plasma membrane; membrane; microtubule cytoskeleton; growth cone; plasma membrane; synapse; axon; soma; dendrite; neuron projection; microtubule; clathrin-coated vesicle; presynapse; dendritic spine; postsynaptic density; cytoplasmic vesicle; Schaffer collateral - CA1 synapse; glutamatergic synapse;
Biological process	regulation of protein phosphorylation; negative regulation of protein phosphorylation; regulation of neurotransmitter levels; positive regulation of protein phosphorylation; intracellular signal transduction; axonogenesis; negative regulation of protein kinase activity; dendrite morphogenesis; synapse organization; protein stabilization; Wnt signaling pathway; transcription by RNA polymerase II; negative regulation of protein binding; receptor clustering; planar cell polarity pathway involved in neural tube closure; axon guidance; positive regulation of transcription, DNA-templated; positive regulation of Wnt signaling pathway; multicellular organism development; Wnt signaling pathway, planar cell polarity pathway; protein localization to microtubule; neuromuscular junction development; cochlea morphogenesis; neural tube development; cytoplasmic microtubule organization; positive regulation of neuron projection development; axon extension; protein localization to nucleus; canonical Wnt signaling pathway; social behavior; skeletal muscle acetylcholine-gated channel clustering; collateral sprouting; convergent extension involved in neural plate elongation; negative regulation of canonical Wnt signaling pathway; neurotransmitter secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; convergent extension involved in organogenesis; prepulse inhibition; positive regulation of canonical Wnt signaling pathway; beta-catenin destruction complex disassembly; dendritic spine morphogenesis; positive regulation of excitatory postsynaptic potential; presynapse assembly; positive regulation of protein localization to presynapse; non-canonical Wnt signaling pathway; postsynapse organization; positive regulation of neuron projection arborization; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	1855
	13542
	ENSG00000107404
	ENSMUSG00000029071
	O14640
	P51141
	NM_004421; NM_181870; NM_182779; NM_001330311
	NM_010091; NM_001302342; NM_001356381
	NP_001317240; NP_004412
	NP_034221; NP_001343310
	Wikidata
View/Edit Human	View/Edit Mouse

Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene.