DVL2

DVL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2REY, 3CBX, 3CBY, 3CBZ, 3CC0, 4WIP
Identifiers
Aliases	DVL2, dishevelled segment polarity protein 2
External IDs	OMIM: 602151; MGI: 106613; HomoloGene: 20927; GeneCards: DVL2; OMA:DVL2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,234,517 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,903,127 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; stromal cell of endometrium; ; left ovary; ; ectocervix; ; right ovary; ; body of uterus; ; right hemisphere of cerebellum; ; canal of the cervix; ; anterior pituitary; ; ganglionic eminence;
	Top expressed in
	yolk sac; ; ventricular zone; ; granulocyte; ; epiblast; ; superior frontal gyrus; ; neural layer of retina; ; spermatocyte; ; genital tubercle; ; tail of embryo; ; dermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein domain specific binding; frizzled binding; protein self-association; protein binding; identical protein binding; protein kinase binding;
Cellular component	membrane; clathrin-coated endocytic vesicle; plasma membrane; apical part of cell; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; nucleus; cytosol; nucleoplasm; aggresome; lateral plasma membrane; nuclear body;
Biological process	non-canonical Wnt signaling pathway; positive regulation of protein phosphorylation; intracellular signal transduction; positive regulation of protein tyrosine kinase activity; heart morphogenesis; canonical Wnt signaling pathway involved in regulation of cell proliferation; positive regulation of DNA-binding transcription factor activity; transcription by RNA polymerase II; hippo signaling; positive regulation of transcription, DNA-templated; multicellular organism development; positive regulation of GTPase activity; protein complex oligomerization; cochlea morphogenesis; convergent extension involved in neural plate elongation; negative regulation of canonical Wnt signaling pathway; segmentation; convergent extension involved in organogenesis; positive regulation of canonical Wnt signaling pathway; neural tube closure; heart development; Wnt signaling pathway; outflow tract morphogenesis; canonical Wnt signaling pathway; segment specification; positive regulation of JUN kinase activity; planar cell polarity pathway involved in neural tube closure; Wnt signaling pathway, planar cell polarity pathway; beta-catenin destruction complex disassembly; membrane organization; positive regulation of neuron projection arborization;
	Sources:Amigo / QuickGO
Orthologs
	1856
	13543
	ENSG00000004975
	ENSMUSG00000020888
	O14641
	Q60838
	NM_004422
	NM_007888
	NP_004413
	NP_031914
	Wikidata
View/Edit Human	View/Edit Mouse

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.