DVL3

DVL3
Identifiers
Aliases	DVL3, DRS3, dishevelled segment polarity protein 3
External IDs	OMIM: 601368; MGI: 108100; HomoloGene: 20928; GeneCards: DVL3; OMA:DVL3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	184,173,614 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	20,352,760 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; gastric mucosa; ; muscle layer of sigmoid colon; ; body of uterus; ; apex of heart; ; sural nerve; ; right ovary; ; left uterine tube; ; left ovary;
	Top expressed in
	cardiac muscle tissue of left ventricle; ; external carotid artery; ; internal carotid artery; ; genital tubercle; ; choroid plexus of fourth ventricle; ; trigeminal ganglion; ; tail of embryo; ; molar; ; ventricular zone; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; frizzled binding; protease binding; protein binding; protein heterodimerization activity; signaling receptor binding;
Cellular component	cytoplasm; cytosol;
Biological process	positive regulation of protein phosphorylation; intracellular signal transduction; positive regulation of JUN kinase activity; protein stabilization; Wnt signaling pathway; positive regulation of transcription, DNA-templated; multicellular organism development; positive regulation of GTPase activity; negative regulation of canonical Wnt signaling pathway; beta-catenin destruction complex disassembly; non-canonical Wnt signaling pathway; non-canonical Wnt signaling pathway via JNK cascade; canonical Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway; planar cell polarity pathway involved in neural tube closure; positive regulation of neuron projection arborization;
	Sources:Amigo / QuickGO
Orthologs
	1857
	13544
	ENSG00000161202
	ENSMUSG00000003233
	Q92997
	Q61062
	NM_004423
	NM_007889; NM_001347176
	NP_004414
	NP_001334105; NP_031915
	Wikidata
View/Edit Human	View/Edit Mouse

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.