DYNC1H1

DYNC1H1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BOR, 2BOT
Identifiers
Aliases	DYNC1H1, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22, CMT2O, dynein cytoplasmic 1 heavy chain 1
External IDs	OMIM: 600112; MGI: 103147; HomoloGene: 1053; GeneCards: DYNC1H1; OMA:DYNC1H1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	102,056,443 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	110,633,379 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; prefrontal cortex; ; stromal cell of endometrium; ; right frontal lobe; ; right hemisphere of cerebellum; ; Brodmann area 9; ; postcentral gyrus; ; lateral nuclear group of thalamus; ; C1 segment;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; CA3 field; ; entorhinal cortex; ; superior frontal gyrus; ; perirhinal cortex; ; ventricular zone; ; external carotid artery; ; central gray substance of midbrain; ; facial motor nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; ATPase activity; protein binding; dynein light intermediate chain binding; cytoskeletal motor activity; ATP binding; RNA binding; minus-end-directed microtubule motor activity; dynein light chain binding; dynein intermediate chain binding;
Cellular component	cytoplasm; cytosol; centrosome; membrane; filopodium; cytoplasmic dynein complex; dynein complex; microtubule; extracellular exosome; cytoskeleton; extracellular matrix; extracellular region; azurophil granule lumen; cytoplasmic microtubule; cell cortex; axon cytoplasm;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; establishment of spindle localization; mitotic spindle organization; endoplasmic reticulum to Golgi vesicle-mediated transport; microtubule-based movement; G2/M transition of mitotic cell cycle; P-body assembly; stress granule assembly; neutrophil degranulation; ciliary basal body-plasma membrane docking; regulation of mitotic spindle organization; positive regulation of intracellular transport; regulation of metaphase plate congression; positive regulation of spindle assembly; cytoplasmic microtubule organization; minus-end-directed vesicle transport along microtubule; cell cycle; cell division; sister chromatid cohesion; regulation of G2/M transition of mitotic cell cycle; transport; positive regulation of cold-induced thermogenesis; mitotic cell cycle; nuclear migration; retrograde axonal transport;
	Sources:Amigo / QuickGO
Orthologs
	1778
	13424
	ENSG00000197102
	ENSMUSG00000018707
	Q14204
	Q9JHU4
	NM_001376
	NM_030238
	NP_001367
	NP_084514
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoplasmic dynein 1 heavy chain 1 is a protein that in humans is encoded by the DYNC1H1 gene. Dynein is a molecular motor protein that is responsible for the transport of numerous cellular cargoes to minus ends of microtubules, which are typically found in the center of a cell, or the cell body of neurons. It is located on the 14th chromosome at position 14q32.31. Cytoplasmic dynein transports cargoes along the axon in the retrograde direction, bringing materials from the axon to the cell body. Dynein heavy chain binds microtubules and hydrolyzes ATP at its C-terminal head. It binds cargo via interaction with other dynein subunits at its N-terminal tail.