DYNLRB1

DYNLRB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z09, 2B95, 2E8J, 2HZ5
Identifiers
Aliases	DYNLRB1, BITH, BLP, DNCL2A, DNLC2A, ROBLD1, dynein light chain roadblock-type 1
External IDs	OMIM: 607167; MGI: 1914318; HomoloGene: 69161; GeneCards: DYNLRB1; OMA:DYNLRB1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	34,540,958 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,092,197 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; right frontal lobe; ; anterior cingulate cortex; ; right hemisphere of cerebellum; ; tibial nerve; ; C1 segment; ; islet of Langerhans; ; left coronary artery; ; popliteal artery; ; tibial arteries;
	Top expressed in
	genital tubercle; ; supraoptic nucleus; ; tail of embryo; ; neural layer of retina; ; seminal vesicula; ; yolk sac; ; dentate gyrus of hippocampal formation granule cell; ; ascending aorta; ; aortic valve; ; ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; microtubule motor activity; cytoskeletal motor activity; dynein intermediate chain binding;
Cellular component	centrosome; ciliary tip; cytoskeleton; membrane; cytoplasm; microtubule; cilium; cytoplasmic dynein complex; dynein complex; outer dynein arm;
Biological process	visual behavior; microtubule-based movement; intraciliary transport involved in cilium assembly; transport; response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	83658
	67068
	ENSG00000125971
	ENSMUSG00000047459
	Q9NP97
	P62627
NM_001281727; NM_001281728; NM_001281729; NM_014183; NM_177953;
	NM_001319157
	NM_001291108; NM_025947
	NP_001306086; NP_054902; NP_001369294; NP_001369295; NP_001369296
	NP_001278037; NP_080223
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.

This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.