Defiance, Missouri
| Defiance | |
|---|---|
| Standard Oil station in Defiance, Missouri | |
| Coordinates: 38°37′56″N 90°46′42″W / 38.63222°N 90.77833°W | |
| Country | United States | 
| State | Missouri | 
| County | Saint Charles | 
| Area | |
|  • Total | 56.120 sq mi (145.350 km2) | 
| • Land | 54.760 sq mi (141.828 km2) | 
| • Water | 1.360 sq mi (3.522 km2) | 
| Population  (2020) | |
|  • Total | 159 | 
| • Density | 2.8/sq mi (1.1/km2) | 
| Time zone | UTC-6 (Central (CST)) | 
| • Summer (DST) | UTC-5 (CDT) | 
| ZIP codes | 63341 | 
| FIPS code | 29-18910 | 
Defiance is an unincorporated community and census-designated place in Saint Charles County, Missouri, United States. As of the 2020 census, the population was 159.