Delta Blues Museum

Yazoo and Mississippi Valley Passenger Depot
Exterior of the museum in 2017
LocationBounded by N. Edwards, Sharkey and Issaquena Aves., and the ICRR main track, Clarksdale, Mississippi, United States
Coordinates34°12′3″N 90°34′15″W / 34.20083°N 90.57083°W / 34.20083; -90.57083
Built1926 (1926)
NRHP reference No.95001194
Added to NRHPOctober 31, 1995

The Delta Blues Museum in Clarksdale, Mississippi, United States, is a museum dedicated to collecting, preserving, and providing public access to and awareness of the musical genre known as the blues. Along with holdings of significant blues-related memorabilia, the museum also exhibits and collects art portraying the blues tradition, including works by sculptor Floyd Shaman and photographer Birney Imes.

The museum is located in the Yazoo and Mississippi Valley Passenger Depot, also known as Illinois Central Passenger Depot or Clarksdale Passenger Depot, which was built in 1926 and listed on the National Register of Historic Places in 1995.