Desmoplakin

DSP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3R6N, 1LM5, 1LM7, 5DZZ
Identifiers
Aliases	DSP, DCWHKTA, DP, DPI, DPII, desmoplakin
External IDs	OMIM: 125647; MGI: 109611; HomoloGene: 37922; GeneCards: DSP; OMA:DSP - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	7,586,714 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	38,382,553 bp
RNA expression pattern
	Top expressed in
	skin of hip; ; skin of thigh; ; hair follicle; ; gingival epithelium; ; human penis; ; vulva; ; skin of arm; ; oral cavity; ; nipple; ; mucosa of pharynx;
	Top expressed in
	conjunctival fornix; ; skin of external ear; ; corneal stroma; ; epidermis; ; hair follicle; ; skin of back; ; ascending aorta; ; myocardium of ventricle; ; aortic valve; ; cardiac muscle tissue of left ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; scaffold protein binding; structural molecule activity; structural constituent of cytoskeleton; protein binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; cell adhesion molecule binding; protein kinase C binding; RNA binding;
Cellular component	cytoplasm; membrane; intercalated disc; cell-cell junction; plasma membrane; desmosome; cell junction; basolateral plasma membrane; fascia adherens; extracellular exosome; cytoskeleton; intermediate filament; nucleus; extracellular matrix; cornified envelope; ficolin-1-rich granule membrane;
Biological process	intermediate filament organization; desmosome organization; ventricular compact myocardium morphogenesis; wound healing; bundle of His cell-Purkinje myocyte adhesion involved in cell communication; keratinocyte differentiation; peptide cross-linking; protein localization to adherens junction; epidermis development; intermediate filament cytoskeleton organization; adherens junction organization; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; skin development; keratinization; neutrophil degranulation; cornification; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1832
	109620
	ENSG00000096696
	ENSMUSG00000054889
	P15924
	E9Q557
	NM_001008844; NM_004415; NM_001319034
	NM_023842
	NP_001008844; NP_001305963; NP_004406
	NP_076331
	Wikidata
View/Edit Human	View/Edit Mouse

Desmoplakin is a protein in humans that is encoded by the DSP gene. Desmoplakin is a critical component of desmosome structures in cardiac muscle and epidermal cells, which function to maintain the structural integrity at adjacent cell contacts. In cardiac muscle, desmoplakin is localized to intercalated discs which mechanically couple cardiac cells to function in a coordinated syncytial structure. Mutations in desmoplakin have been shown to play a role in dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy, where it may present with acute myocardial injury; striate palmoplantar keratoderma, Carvajal syndrome and paraneoplastic pemphigus.