Destrin
| Destrin (actin binding protein) | |||||||
|---|---|---|---|---|---|---|---|
Nuclear magnetic resonance determined configuration of the tertiary structure of Destrin. | |||||||
| Identifiers | |||||||
| Symbol | DSTN | ||||||
| Alt. symbols | ADF | ||||||
| NCBI gene | 11034 | ||||||
| HGNC | 15750 | ||||||
| OMIM | 609114 | ||||||
| RefSeq | NM_006870 | ||||||
| UniProt | P60981 | ||||||
| Other data | |||||||
| Locus | Chr. 20 p12.1 | ||||||
| |||||||
Destrin or DSTN (also known as actin depolymerizing factor or ADF) is a protein which in humans is encoded by the DSTN gene. Destrin is a component protein in microfilaments.
The product of this gene belongs to the actin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.