Diazoxide

Diazoxide
Clinical data
Trade names	Proglycem, others
AHFS/Drugs.com	Monograph
License data	US DailyMed: Diazoxide;
Pregnancy; category	AU: C;
Routes of; administration	By mouth, intravenous
ATC code	C02DA01 (WHO) V03AH01 (WHO);
Legal status
Legal status	CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Protein binding	90%
Metabolism	Liver oxidation and sulfate conjugation
Elimination half-life	21-45 hours
Excretion	Kidney
Identifiers
	IUPAC name 7-Chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide;
CAS Number	364-98-7 ;
PubChem CID	3019;
IUPHAR/BPS	2409;
DrugBank	DB01119 ;
ChemSpider	2911 ;
UNII	O5CB12L4FN;
KEGG	D00294 ;
ChEBI	CHEBI:4495 ;
ChEMBL	ChEMBL181 ;
CompTox Dashboard (EPA)	DTXSID7022914 ;
ECHA InfoCard	100.006.063
Chemical and physical data
Formula	C8H7ClN2O2S
Molar mass	230.67 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	330 to 331 °C (626 to 628 °F)
	SMILES Clc1ccc2c(c1)S(=O)(=O)/N=C(\N2)C;
	InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) ; Key:GDLBFKVLRPITMI-UHFFFAOYSA-N ;
	(verify)

Diazoxide, sold under the brand name Proglycem among others, is a medication used to treat low blood sugar due to a number of specific causes. This includes islet cell tumors that cannot be removed and leucine sensitivity. It can also be used in refractory cases of sulfonylurea toxicity. It is taken by mouth.

Diazoxide, used as the salt diazoxide choline, and sold under the brand name Vykat XR, is used for the treatment of hyperphagia in people with Prader-Willi syndrome. It was approved for this use in the United States in March 2025.

Common side effects include high blood sugar, fluid retention, low blood platelets, a fast heart rate, increased hair growth, and nausea. Other severe side effects include pulmonary hypertension and heart failure. It is chemically similar to thiazide diuretics. It works by decreasing insulin release from the pancreas and increasing glucose release by the liver.

Diazoxide was approved for medical use in the United States in 1973. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.