Dicycloverine

Dicycloverine
Clinical data
Trade names	Byclomine, Bentyl, Dibent, others
AHFS/Drugs.com	Monograph
MedlinePlus	a684007
License data	US DailyMed: Dicyclomine;
Pregnancy; category	AU: B1;
Routes of; administration	By mouth, intramuscular
Drug class	Antimuscarinic
ATC code	A03AA07 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Protein binding	>99%
Elimination half-life	5 hours
Identifiers
	IUPAC name 2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate;
CAS Number	77-19-0 ;
PubChem CID	3042;
IUPHAR/BPS	355;
DrugBank	DB00804 ;
ChemSpider	2934 ;
UNII	4KV4X8IF6V;
KEGG	D07820 ;
ChEBI	CHEBI:4514 ;
ChEMBL	ChEMBL1123 ;
CompTox Dashboard (EPA)	DTXSID1022926 ;
ECHA InfoCard	100.000.919
Chemical and physical data
Formula	C19H35NO2
Molar mass	309.494 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCCN(CC)CC)C1(CCCCC1)C2CCCCC2;
	InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3 ; Key:CURUTKGFNZGFSE-UHFFFAOYSA-N ;
	(verify)

Dicycloverine, also known as dicyclomine, sold under the brand name Bentyl among others, is a medication that is used to treat spasms of the intestines such as those that occur in irritable bowel syndrome (IBS). It is taken by mouth or by injection into a muscle. While it has been used in baby colic and enterocolitis, evidence does not support these uses.

Common side effects include dry mouth, blurred vision, weakness, sleepiness, and lightheadedness. Serious side effects may include psychosis and breathing problems in babies. Use in pregnancy appears to be safe while use during breastfeeding is not recommended. How it works is not entirely clear.

Dicycloverine was approved for medical use in the United States in 1950. It is available as a generic medication. In 2022, it was the 176th most commonly prescribed medication in the United States, with more than 2 million prescriptions.