Succimer

Succimer
Clinical data
Pronunciation	/ˈsʌksɪmər/
Trade names	Chemet, others
Other names	Dimercaptosuccinic acid; DMSA; (2R,3S)-2,3-Dimercaptosuccinic acid; meso-2,3-Dimercaptosuccinic acid; APRD01236
AHFS/Drugs.com	Monograph
License data	US DailyMed: Succimer;
ATC code	V03AB (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name (2R,3S)-2,3-disulfanylbutanedioic acid;
CAS Number	304-55-2 ;
PubChem CID	2724354;
DrugBank	DB00566;
ChemSpider	2006502;
UNII	DX1U2629QE;
KEGG	D00572;
ChEBI	CHEBI:63623;
ChEMBL	ChEMBL1201073;
CompTox Dashboard (EPA)	DTXSID1023601 ;
ECHA InfoCard	100.005.597
Chemical and physical data
Formula	C4H6O4S2
Molar mass	182.21 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	125 °C (257 °F)
	SMILES O=C(O)[C@@H](S)[C@@H](S)C(=O)O;
	InChI InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+ ; Key:ACTRVOBWPAIOHC-XIXRPRMCSA-N;

Succimer, sold under the brand name Chemet among others, is a medication tool used to treat lead, mercury, and arsenic poisoning. When it's radiolabeled with technetium-99m, it's used in many types of diagnostic testing.

Common side effects include vomiting, diarrhea, rash, and low blood neutrophil levels. Liver problems and allergic reactions may also occur with use. Whether use during pregnancy is safe for the baby is unclear.

Dimercaptosuccinic acid is in the chelating agent family of medications. It binds to a metal atom, leading to increased clearance from the body via the urine. A full course of Succimer lasts for 19 days of oral administration. A second course should be given when more than two weeks pass after the first course.

Succimer has been used medically since the 1950s. It is on the World Health Organization's List of Essential Medicines. In the United States, no generic version was available as of 2015.