Diphtheria toxin
| tox diphtheria toxin precursor | |||||||
|---|---|---|---|---|---|---|---|
Cartoon representation of the diphtheria toxin protein | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | tox | ||||||
| Entrez | 2650491 | ||||||
| RefSeq (Prot) | NP_938615 | ||||||
| UniProt | P00587 | ||||||
| Other data | |||||||
| EC number | 2.4.2.36 | ||||||
| Chromosome | genome: 0.19 - 0.19 Mb | ||||||
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| Diphtheria toxin, C domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Diphtheria_C | ||||||||
| Pfam | PF02763 | ||||||||
| Pfam clan | CL0084 | ||||||||
| InterPro | IPR022406 | ||||||||
| SCOP2 | 1ddt / SCOPe / SUPFAM | ||||||||
| TCDB | 1.C.7 | ||||||||
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| Diphtheria toxin, T domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Diphtheria_T | ||||||||
| Pfam | PF02764 | ||||||||
| InterPro | IPR022405 | ||||||||
| SCOP2 | 1ddt / SCOPe / SUPFAM | ||||||||
| TCDB | 1.C.7 | ||||||||
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| Diphtheria toxin, R domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Diphtheria_R | ||||||||
| Pfam | PF01324 | ||||||||
| InterPro | IPR022404 | ||||||||
| SCOP2 | 1ddt / SCOPe / SUPFAM | ||||||||
| TCDB | 1.C.7 | ||||||||
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Diphtheria toxin is an exotoxin secreted mainly by Corynebacterium diphtheriae but also by Corynebacterium ulcerans and Corynebacterium pseudotuberculosis, the pathogenic bacterium that causes diphtheria. The toxin gene is encoded by a prophage called corynephage β. The toxin causes the disease in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis.