Discoidin domain-containing receptor 2

DDR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WUH, 2Z4F
Identifiers
Aliases	DDR2, MIG20a, NTRKR3, TKT, TYRO10, discoidin domain receptor tyrosine kinase 2, WRCN
External IDs	OMIM: 191311; MGI: 1345277; HomoloGene: 68505; GeneCards: DDR2; OMA:DDR2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	162,787,405 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	169,938,331 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; tendon of biceps brachii; ; vena cava; ; synovial joint; ; Achilles tendon; ; caput epididymis; ; cartilage tissue; ; tibia; ; buccal mucosa cell; ; pericardium;
	Top expressed in
	calvaria; ; ascending aorta; ; dermis; ; lumbar spinal ganglion; ; aortic valve; ; body of femur; ; fossa; ; ankle; ; iris; ; stroma of bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase collagen receptor activity; protein tyrosine kinase activity; ATP binding; collagen binding;
Cellular component	integral component of membrane; membrane; focal adhesion; integral component of plasma membrane; extracellular exosome; apical plasma membrane; plasma membrane; actin cytoskeleton; receptor complex;
Biological process	collagen-activated tyrosine kinase receptor signaling pathway; ossification; phosphorylation; collagen fibril organization; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of bone mineralization; positive regulation of fibroblast proliferation; biomineral tissue development; positive regulation of DNA-binding transcription factor activity; extracellular matrix organization; regulation of extracellular matrix disassembly; positive regulation of extracellular matrix disassembly; protein phosphorylation; cell adhesion; positive regulation of osteoblast differentiation; chondrocyte proliferation; positive regulation of cell population proliferation; peptidyl-tyrosine phosphorylation; endochondral bone growth; positive regulation of fibroblast migration; signal transduction; positive regulation of protein kinase activity; protein autophosphorylation; regulation of cell-matrix adhesion; cell-matrix adhesion; cell differentiation; regulation of extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	4921
	18214
	ENSG00000162733
	ENSMUSG00000026674
	Q16832
	Q62371
	NM_001014796; NM_006182; NM_001354982; NM_001354983
	NM_022563
	NP_001014796; NP_006173; NP_001341911; NP_001341912
	NP_072075
	Wikidata
View/Edit Human	View/Edit Mouse

Discoidin domain-containing receptor 2, also known as CD167b (cluster of differentiation 167b), is a protein that in humans is encoded by the DDR2 gene. Discoidin domain-containing receptor 2 is a receptor tyrosine kinase (RTK).