Disulfiram-alcohol reaction

Disulfiram-alcohol reaction (DAR)
Other namesDisulfiram ethanol reaction (DER), Antabuse effect, acetaldehyde syndrome
Alcohol flush reaction is a visible effect of DAR.
SpecialtyToxicology
SymptomsFlush, nausea, lightheadedness, headache, sweating, vomiting, vertigo, etc
CausesIngestion of disulfiram with alcohol

Disulfiram-alcohol reaction (DAR) is the effect of the interaction in the human body of alcohol drunk with disulfiram or some types of mushrooms. The DAR is key to disulfiram therapy that is widely used for alcohol-aversive treatment and management of other addictions (e.g. cocaine use). Once disulfiram-treated patients take alcohol, even in small doses, they experience strong unpleasant sensations (flush, nausea, lightheadedness, headache, sweating, vomiting, and vertigo).

Disulfiram has been used to treat alcoholism since 1948 after its accidental discovery in Denmark.

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