Dopamine receptor D3

DRD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PBL
Identifiers
Aliases	DRD3, D3DR, ETM1, FET1, dopamine receptor D3
External IDs	OMIM: 126451; MGI: 94925; HomoloGene: 623; GeneCards: DRD3; OMA:DRD3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	114,199,407 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	43,643,295 bp
RNA expression pattern
	Top expressed in
	testicle; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; granulocyte; ; prefrontal cortex; ; lymph node; ; Hypothalamus; ; left testis; ; right testis;
	Top expressed in
	morula; ; zygote; ; superior frontal gyrus; ; right ventricle; ; lumbar subsegment of spinal cord; ; ventricular zone; ; meninges; ; dentate gyrus of hippocampal formation granule cell; ; blastocyst; ; tibiofemoral joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity; G protein-coupled receptor activity; dopamine neurotransmitter receptor activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; dopamine binding; protein domain specific binding; D1 dopamine receptor binding; adrenergic receptor activity;
Cellular component	endocytic vesicle; apical part of cell; cell projection; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; dopaminergic synapse; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic density membrane;
Biological process	negative regulation of sodium:proton antiporter activity; dopamine receptor signaling pathway; dopamine metabolic process; regulation of circadian sleep/wake cycle, sleep; negative regulation of dopamine receptor signaling pathway; positive regulation of cell population proliferation; regulation of dopamine uptake involved in synaptic transmission; response to histamine; response to ethanol; prepulse inhibition; social behavior; learning; positive regulation of renal sodium excretion; arachidonic acid secretion; negative regulation of protein secretion; negative regulation of transcription by RNA polymerase II; gastric emptying; regulation of blood volume by renin-angiotensin; regulation of locomotion involved in locomotory behavior; cellular calcium ion homeostasis; regulation of locomotion; learning or memory; response to amphetamine; positive regulation of transcription by RNA polymerase II; positive regulation of cytokinesis; signal transduction; regulation of lipid metabolic process; regulation of multicellular organism growth; visual learning; G protein-coupled receptor internalization; regulation of dopamine secretion; negative regulation of protein kinase B signaling; adenylate cyclase-activating dopamine receptor signaling pathway; locomotory behavior; behavioral response to cocaine; negative regulation of blood pressure; acid secretion; musculoskeletal movement, spinal reflex action; positive regulation of dopamine receptor signaling pathway; circadian regulation of gene expression; response to morphine; negative regulation of oligodendrocyte differentiation; adenylate cyclase-inhibiting dopamine receptor signaling pathway; positive regulation of mitotic nuclear division; response to cocaine; synaptic transmission, dopaminergic; G protein-coupled receptor signaling pathway; autophagy; negative regulation of apoptotic process; regulation of neurotransmitter uptake; regulation of postsynaptic neurotransmitter receptor internalization; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; adenylate cyclase-activating adrenergic receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1814
	13490
	ENSG00000151577
	ENSMUSG00000022705
	P35462
	P30728
NM_000796; NM_001282563; NM_001290809; NM_033658; NM_033659;
	NM_033660; NM_033663
	NM_007877
	NP_000787; NP_001269492; NP_001277738; NP_387512
	NP_031903
	Wikidata
View/Edit Human	View/Edit Mouse

Dopamine receptor D₃ is a protein that in humans is encoded by the DRD3 gene.

This gene encodes the D₃ subtype of the dopamine receptor. The D₃ subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson's disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). On a side note, it is also the Dopamine Receptor sub-type possessing the highest binding affinity for Dopamine itself and may explain why non-ergoline Dopamine Agonists are D₃-preferring