DBN1

DBN1
Identifiers
Aliases	DBN1, D0S117E, drebrin 1
External IDs	OMIM: 126660; MGI: 1931838; HomoloGene: 3236; GeneCards: DBN1; OMA:DBN1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,474,401 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,635,924 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; sural nerve; ; stromal cell of endometrium; ; ventricular zone; ; gastric mucosa; ; ascending aorta; ; left uterine tube; ; Descending thoracic aorta; ; nucleus accumbens; ; body of uterus;
	Top expressed in
	maxillary prominence; ; mandibular prominence; ; ventricular zone; ; ganglionic eminence; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; olfactory tubercle; ; subiculum; ; neural tube; ; lateral septal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	profilin binding; protein binding; actin binding; cadherin binding;
Cellular component	cell projection; membrane; cell-cell junction; intracellular anatomical structure; cell junction; dendrite; cell cortex; gap junction; actomyosin; cytoplasm; growth cone; plasma membrane; actin cytoskeleton; cytoskeleton; postsynaptic density; cortical cytoskeleton; postsynaptic membrane; glutamatergic synapse; postsynaptic cytosol;
Biological process	cell differentiation; cell communication by electrical coupling; regulation of dendrite development; nervous system development; generation of neurons; multicellular organism development; neural precursor cell proliferation; regulation of neuronal synaptic plasticity; maintenance of protein location in cell; cell communication by chemical coupling; actin filament organization; positive regulation of synaptic plasticity; cytoplasmic sequestering of protein; positive regulation of dendritic spine morphogenesis; positive regulation of receptor localization to synapse;
	Sources:Amigo / QuickGO
Orthologs
	1627
	56320
	ENSG00000113758
	ENSMUSG00000034675
	Q16643
	Q9QXS6
NM_004395; NM_080881; NM_001363541; NM_001364151; NM_001364152;
	NM_001393630; NM_001393631
	NM_001177371; NM_001177372; NM_019813
	NP_004386; NP_543157; NP_001350470; NP_001351080; NP_001351081
	NP_001170842; NP_001170843; NP_062787
	Wikidata
View/Edit Human	View/Edit Mouse

Drebrin is a protein that in humans is encoded by the DBN1 gene.

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.