Droperidol

Droperidol
Clinical data
Pronunciation	/droʊˈpɛrIdɔːl/
Pregnancy; category	AU: C;
Routes of; administration	Intravenous, Intramuscular
Drug class	Typical antipsychotic
ATC code	N05AD08 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class C1 (Other controlled substances); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	2.3 hours
Identifiers
	IUPAC name 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one;
CAS Number	548-73-2;
PubChem CID	3168;
DrugBank	DB00450;
ChemSpider	3056;
UNII	O9U0F09D5X;
KEGG	D00308;
ChEMBL	ChEMBL1108 ;
CompTox Dashboard (EPA)	DTXSID6022973 ;
ECHA InfoCard	100.008.144
Chemical and physical data
Formula	C22H22FN3O2
Molar mass	379.435 g·mol−1
3D model (JSmol)	Interactive image; Interactive image;
	SMILES c1ccc2c(c1)nc(n2C3=CCN(CC3)CCCC(=O)c4ccc(cc4)F)O; ; Fc1ccc(cc1)C(=O)CCCN2CC=C(CC2)N3c4ccccc4NC3=O;
	InChI InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28); Key:RMEDXOLNCUSCGS-UHFFFAOYSA-N;

Droperidol /droʊˈpɛrɪdɔːl/ (Inapsine, Droleptan, Dridol, Xomolix, Innovar [combination with fentanyl]) is an antidopaminergic drug used as an antiemetic (that is, to prevent or treat nausea) and as an antipsychotic. Droperidol is also often used as a rapid sedative in intensive-care treatment, and where "agitation aggression or violent behavior" are present.

Clinical data


Pronunciation	/droʊˈpɛrIdɔːl/
Pregnancy category	AU: C
Routes of administration	Intravenous, Intramuscular
Drug class	Typical antipsychotic
ATC code	N05AD08 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) BR: Class C1 (Other controlled substances) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	2.3 hours
Identifiers
IUPAC name 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
CAS Number	548-73-2
PubChem CID	3168
DrugBank	DB00450
ChemSpider	3056
UNII	O9U0F09D5X
KEGG	D00308
ChEMBL	ChEMBL1108^Y
CompTox Dashboard (EPA)	DTXSID6022973
ECHA InfoCard	100.008.144
Chemical and physical data
Formula	C₂₂H₂₂FN₃O₂
Molar mass	379.435 g·mol⁻¹
3D model (JSmol)	Interactive image Interactive image
SMILES c1ccc2c(c1)nc(n2C3=CCN(CC3)CCCC(=O)c4ccc(cc4)F)O Fc1ccc(cc1)C(=O)CCCN2CC=C(CC2)N3c4ccccc4NC3=O
InChI InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28) Key:RMEDXOLNCUSCGS-UHFFFAOYSA-N