Drotaverine

Drotaverine
Clinical data
Trade names	No-Spa, Doverin
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, intravenous, intramuscular
ATC code	A03AD02 (WHO) ;
Legal status
Legal status	OTC (tablets), Rx-only (solution for injection) (RU);
Pharmacokinetic data
Bioavailability	Highly variable (~65%), peak at 45–60 min
Protein binding	95–98%
Metabolism	Hepatic
Elimination half-life	7–16 hours
Excretion	>50% in urine and ~30% in bile
Identifiers
	IUPAC name (Z)-1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline;
CAS Number	14009-24-6 ;
PubChem CID	1712095;
DrugBank	DB06751 ;
ChemSpider	1361582 ;
UNII	98QS4N58TW;
KEGG	D07879 ;
ChEMBL	ChEMBL551978 ;
CompTox Dashboard (EPA)	DTXSID60161227 ;
ECHA InfoCard	100.110.916
Chemical and physical data
Formula	C24H31NO4
Molar mass	397.515 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O(c1ccc(cc1OCC)\C=C3\c2c(cc(OCC)c(OCC)c2)CCN3)CC;
	InChI InChI=1S/C24H31NO4/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20/h9-10,13-16,25H,5-8,11-12H2,1-4H3/b20-13- ; Key:OMFNSKIUKYOYRG-MOSHPQCFSA-N ;
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Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth and to relieve smooth muscle spasms in the gastrointestinal tract, urinary system, and gall bladder.

It is structurally related to papaverine, and is a selective inhibitor of phosphodiesterase-4, and has no anticholinergic effects.

It is available in Asia, Central and Eastern Europe (Poland, Hungary, Estonia, Latvia, Lithuania) under several brand names. A popular brand is No-Spa, owned by Sanofi). It is distributed by Sanofi as Но-Шпа (No-shpa) in Russia.