Cadherin-1

CDH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1O6S, 2O72, 2OMT, 2OMU, 2OMV, 2OMX, 2OMY, 2OMZ, 3FF7, 3FF8, 3L6X, 3L6Y, 4ZT1, 4ZTE
Identifiers
Aliases	CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, BCDS1, E-cadherin, uvomorulin
External IDs	OMIM: 192090; MGI: 88354; HomoloGene: 20917; GeneCards: CDH1; OMA:CDH1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	68,835,537 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	107,396,878 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; gingival epithelium; ; mucosa of sigmoid colon; ; skin of thigh; ; palpebral conjunctiva; ; skin of hip; ; bronchial epithelial cell; ; duodenum; ; mucosa of ileum; ; epithelium of nasopharynx;
	Top expressed in
	epithelium of stomach; ; left colon; ; transitional epithelium of urinary bladder; ; epithelium of small intestine; ; stria vascularis; ; migratory enteric neural crest cell; ; mucous cell of stomach; ; submandibular gland; ; pyloric antrum; ; left lung lobe;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; ankyrin binding; gamma-catenin binding; beta-catenin binding; GTPase activating protein binding; metal ion binding; cell adhesion molecule binding; cadherin binding; identical protein binding; cytoskeletal protein binding; protein homodimerization activity;
Cellular component	apical junction complex; trans-Golgi network; extracellular region; perinuclear region of cytoplasm; cortical actin cytoskeleton; Golgi apparatus; lamellipodium; cytoplasmic side of plasma membrane; endosome; lateral plasma membrane; catenin complex; actin cytoskeleton; flotillin complex; membrane; extracellular exosome; integral component of membrane; cell junction; cytoplasm; plasma membrane; cell surface; postsynapse; glutamatergic synapse;
Biological process	negative regulation of cell-cell adhesion; positive regulation of transcription, DNA-templated; cellular response to lithium ion; cell adhesion; extracellular matrix organization; cellular response to indole-3-methanol; extracellular matrix disassembly; synapse assembly; pituitary gland development; response to toxic substance; response to organic substance; neuron projection development; adherens junction organization; homophilic cell adhesion via plasma membrane adhesion molecules; entry of bacterium into host cell; protein localization to plasma membrane; cell-cell adhesion; cell morphogenesis; cell-cell junction assembly; regulation of gene expression; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; negative regulation of cell migration; positive regulation of protein import into nucleus; cell-cell adhesion mediated by cadherin; regulation of protein catabolic process at postsynapse, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	999
	12550
	ENSG00000039068
	ENSMUSG00000000303
	P12830
	P09803
	NM_004360; NM_001317184; NM_001317185; NM_001317186
	NM_009864
	NP_001304113; NP_001304114; NP_001304115; NP_004351
	NP_033994
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-1 or Epithelial cadherin (E-cadherin), is a protein that in humans is encoded by the CDH1 gene (not to be confused with the APC/C activator protein CDH1). Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene.