EBF1

EBF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LYR, 3MQI
Identifiers
Aliases	EBF1, COE1, EBF, O/E-1, OLF1, early B-cell factor 1, early B cell factor 1, EBF transcription factor 1
External IDs	OMIM: 164343; MGI: 95275; HomoloGene: 7297; GeneCards: EBF1; OMA:EBF1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	159,099,916 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	45,008,091 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; synovial membrane; ; Achilles tendon; ; oocyte; ; buccal mucosa cell; ; skin of hip; ; cardiac muscle tissue of right atrium; ; parietal pleura; ; vena cava; ; spinal ganglia;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; trigeminal ganglion; ; superior cervical ganglion; ; spinal ganglia; ; neural tube; ; ankle; ; lumbar spinal ganglion; ; subcutaneous adipose tissue; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; DNA-binding transcription factor activity; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; C2H2 zinc finger domain binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1879
	13591
	ENSG00000164330
	ENSMUSG00000057098
	Q9UH73
	Q07802
NM_001290360; NM_024007; NM_182708; NM_001324101; NM_001324103;
	NM_001324106; NM_001324107; NM_001324108; NM_001324109; NM_001324111; NM_001364155; NM_001364156; NM_001364157; NM_001364158; NM_001364159
	NM_001290709; NM_001290710; NM_001290711; NM_007897
NP_001277289; NP_001311030; NP_001311032; NP_001311035; NP_001311036;
	NP_001311037; NP_001311038; NP_001311040; NP_076870; NP_874367; NP_001351084; NP_001351085; NP_001351086; NP_001351087; NP_001351088
NP_001277638; NP_001277639; NP_001277640; NP_031923; NP_001349498;
	NP_001349500; NP_001349503; NP_001349504; NP_001349505; NP_001349506; NP_001349507; NP_001349508
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function. The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells. In addition, EBF1 is also noted for its role in chondrogenic differentiation in limb bud mesenchymal progenitor cells.