Extracellular matrix protein 1

ECM1
Identifiers
Aliases	ECM1, URBWD, extracellular matrix protein 1
External IDs	OMIM: 602201; MGI: 103060; HomoloGene: 3260; GeneCards: ECM1; OMA:ECM1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,513,789 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,646,881 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; mucosa of pharynx; ; stromal cell of endometrium; ; oral cavity; ; tail of epididymis; ; gallbladder; ; amniotic fluid; ; body of tongue; ; epithelium of esophagus; ; corpus epididymis;
	Top expressed in
	esophagus; ; adrenal gland; ; urinary bladder; ; lip; ; zone of skin; ; white adipose tissue; ; human kidney; ; right kidney; ; liver; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-2 receptor binding; signal transducer activity; protease binding; protein C-terminus binding; protein binding; enzyme binding; laminin binding;
Cellular component	extracellular matrix; extracellular exosome; extracellular region; platelet dense granule lumen; extracellular space;
Biological process	regulation of T cell migration; negative regulation of peptidase activity; negative regulation of bone mineralization; positive regulation of endothelial cell proliferation; ossification; regulation of bone mineralization; regulation of transcription by RNA polymerase II; biomineral tissue development; negative regulation of cytokine-mediated signaling pathway; positive regulation of angiogenesis; angiogenesis; positive regulation of I-kappaB kinase/NF-kappaB signaling; inflammatory response; regulation of type 2 immune response; platelet degranulation; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	1893
	13601
	ENSG00000143369
	ENSMUSG00000028108
	Q16610
	Q61508
	NM_022664; NM_001202858; NM_004425
	NM_001252653; NM_007899; NM_001355070
	NP_001189787; NP_004416; NP_073155
	NP_001239582; NP_031925; NP_001341999
	Wikidata
View/Edit Human	View/Edit Mouse

Extracellular matrix protein 1 is a protein that in humans is encoded by the ECM1 gene.

This gene encodes an extracellular protein containing motifs with a cysteine pattern characteristic of the cysteine pattern of the ligand-binding "double-loop" domains of the albumin protein family. This gene maps outside the epidermal differentiation complex (EDC), a cluster of three gene families involved in epidermal differentiation. Alternatively spliced transcript variants encoding distinct isoforms have been described.