ECSIT

ECSIT
Identifiers
Aliases	ECSIT, SITPEC, ECSIT signalling integrator, ECSIT signaling integrator
External IDs	OMIM: 608388; MGI: 1349469; HomoloGene: 8080; GeneCards: ECSIT; OMA:ECSIT - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	11,529,172 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,996,734 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; left ventricle; ; gastrocnemius muscle; ; muscle of thigh; ; right auricle of heart; ; mucosa of transverse colon; ; body of stomach; ; right frontal lobe; ; body of pancreas; ; right lobe of liver;
	Top expressed in
	interventricular septum; ; muscle of thigh; ; right kidney; ; skeletal muscle tissue; ; temporal muscle; ; right ventricle; ; digastric muscle; ; sternocleidomastoid muscle; ; extraocular muscle; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on NAD(P)H; protein binding;
Cellular component	cytoplasm; mitochondrial inner membrane; mitochondrion; nucleus; nucleoplasm; cytosol;
Biological process	immune system process; innate immune response; regulation of oxidoreductase activity; mitochondrial respiratory chain complex I assembly;
	Sources:Amigo / QuickGO
Orthologs
	51295
	26940
	ENSG00000130159
	ENSMUSG00000066839
	Q9BQ95
	Q9QZH6
	NM_016581; NM_001142464; NM_001142465; NM_001243204
	NM_001253897; NM_001253898; NM_012029
	NP_001135936; NP_001135937; NP_001230133; NP_057665
	NP_001240826; NP_001240827; NP_036159
	Wikidata
View/Edit Human	View/Edit Mouse

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT), also known as SITPEC, is a protein that in humans is encoded by the ECSIT gene. ECSIT is a cytosolic adaptor protein involved in inflammatory responses, embryonic development, and the assembly and stabilization of mitochondrial NADH:ubiquinone oxidoreductase (complex I).