EDEM1

EDEM1
Identifiers
Aliases	EDEM1, EDEM, ER degradation enhancing alpha-mannosidase like protein 1
External IDs	OMIM: 607673; MGI: 2180139; HomoloGene: 33836; GeneCards: EDEM1; OMA:EDEM1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	5,219,958 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	108,836,317 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; thymus; ; liver; ; right lobe of liver; ; lymph node; ; epithelium of nasopharynx; ; decidua; ; appendix; ; tonsil; ; stromal cell of endometrium;
	Top expressed in
	lacrimal gland; ; thymus; ; parotid gland; ; stroma of bone marrow; ; crypt of lieberkuhn of small intestine; ; left lobe of liver; ; granulocyte; ; decidua; ; submandibular gland; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; misfolded protein binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; protein binding; catalytic activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum; endoplasmic reticulum quality control compartment; Golgi membrane; aggresome;
Biological process	N-glycan processing; positive regulation of retrograde protein transport, ER to cytosol; trimming of terminal mannose on C branch; IRE1-mediated unfolded protein response; response to unfolded protein; ubiquitin-dependent glycoprotein ERAD pathway; mannose trimming involved in glycoprotein ERAD pathway; ubiquitin-dependent ERAD pathway;
	Sources:Amigo / QuickGO
Orthologs
	9695
	192193
	ENSG00000134109
	ENSMUSG00000030104
	Q92611
	Q925U4
	NM_014674
	NM_138677
	NP_055489
	NP_619618
	Wikidata
View/Edit Human	View/Edit Mouse

ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.