EDEM2

EDEM2
Identifiers
Aliases	EDEM2, C20orf31, C20orf49, bA4204.1, ER degradation enhancing alpha-mannosidase like protein 2
External IDs	OMIM: 610302; MGI: 1915540; HomoloGene: 10075; GeneCards: EDEM2; OMA:EDEM2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,147,336 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,571,395 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right lobe of liver; ; islet of Langerhans; ; right adrenal gland; ; body of pancreas; ; left adrenal gland; ; mucosa of transverse colon; ; decidua; ; right adrenal cortex;
	Top expressed in
	lacrimal gland; ; decidua; ; islet of Langerhans; ; salivary gland; ; parotid gland; ; crypt of lieberkuhn of small intestine; ; pyloric antrum; ; seminal vesicula; ; epithelium of stomach; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; catalytic activity;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; membrane; endoplasmic reticulum quality control compartment;
Biological process	endoplasmic reticulum unfolded protein response; mannose trimming involved in glycoprotein ERAD pathway; N-glycan processing; positive regulation of retrograde protein transport, ER to cytosol; response to unfolded protein; ubiquitin-dependent glycoprotein ERAD pathway; trimming of terminal mannose on B branch; trimming of terminal mannose on C branch; trimming of first mannose on A branch; trimming of second mannose on A branch;
	Sources:Amigo / QuickGO
Orthologs
	55741
	108687
	ENSG00000088298
	ENSMUSG00000038312
	Q9BV94
	Q8BJT9
	NM_001145025; NM_018217
	NM_145537
	NP_001138497; NP_060687
	NP_663512
	Wikidata
View/Edit Human	View/Edit Mouse

ER degradation-enhancing alpha-mannosidase-like 2 is an enzyme that in humans is encoded by the EDEM2 gene.