Eukaryotic translation elongation factor 1 alpha 1

EEF1A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SYW, 3C5J
Identifiers
Aliases	EEF1A1, CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, eukaryotic translation elongation factor 1 alpha 1, EF1A1, EF1alpha1
External IDs	OMIM: 130590; MGI: 1096881; HomoloGene: 100799; GeneCards: EEF1A1; OMA:EEF1A1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	73,525,587 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	78,396,433 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; stromal cell of endometrium; ; canal of the cervix; ; left ovary; ; right ovary; ; smooth muscle tissue; ; gallbladder; ; body of uterus; ; gonad;
	Top expressed in
	epiblast; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; tail of embryo; ; uterus; ; urinary bladder; ; thymus; ; ovary; ; ganglionic eminence; ; genital tubercle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; tRNA binding; GTP binding; translation elongation factor activity; protein binding; GTPase activity; protein kinase binding; RNA binding; calmodulin binding; kinase binding;
Cellular component	cytoplasm; cytosol; cytoplasmic side of lysosomal membrane; ruffle membrane; nucleolus; cortical actin cytoskeleton; extracellular exosome; nucleus; eukaryotic translation elongation factor 1 complex; extracellular region; extracellular space; secretory granule lumen; ficolin-1-rich granule lumen; plasma membrane; membrane; myelin sheath;
Biological process	regulation of transcription, DNA-templated; translational elongation; transcription, DNA-templated; cellular response to epidermal growth factor stimulus; regulation of chaperone-mediated autophagy; protein biosynthesis; protein methylation; neutrophil degranulation; regulation of D-erythro-sphingosine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	1915
	13627
	ENSG00000156508
	ENSMUSG00000037742
	P68104
	P10126
	NM_001402; NM_001403
	NM_010106
	NP_001393
	NP_034236
	Wikidata
View/Edit Human	View/Edit Mouse

Elongation factor 1-alpha 1 (eEF1a1) is a translation elongation protein, expressed across eukaryotes. In humans, it is encoded by the EEF1A1 gene.

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty's syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes.