EFEMP2

EFEMP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KL7
Identifiers
Aliases	EFEMP2, ARCL1B, FBLN4, MBP1, UPH1, EGF containing fibulin like extracellular matrix protein 2, EGF containing fibulin extracellular matrix protein 2
External IDs	OMIM: 604633; MGI: 1891209; HomoloGene: 32339; GeneCards: EFEMP2; OMA:EFEMP2 - orthologs
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,532,545 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ascending aorta; ; right coronary artery; ; left coronary artery; ; canal of the cervix; ; left uterine tube; ; popliteal artery; ; myometrium; ; left lobe of thyroid gland; ; gastric mucosa;
	Top expressed in
	calvaria; ; stroma of bone marrow; ; molar; ; dermis; ; decidua; ; external carotid artery; ; internal carotid artery; ; ascending aorta; ; umbilical cord; ; efferent ductule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; extracellular matrix structural constituent; protein binding;
Cellular component	extracellular vesicle; extracellular region; basement membrane; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	elastic fiber assembly;
	Sources:Amigo / QuickGO
Orthologs
	30008
	58859
	n/a
	ENSMUSG00000024909
	O95967
	Q9WVJ9
	NM_016938
	NM_001164352; NM_021474; NM_001374680
	NP_058634
	NP_001157824; NP_067449; NP_001361609
	Wikidata
View/Edit Human	View/Edit Mouse

EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene.

A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. EFEMP2 (also known as fibulin-4) contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is widely expressed in a range of adult and fetal tissues.