Ephrin A2

EFNA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WO3
Identifiers
Aliases	EFNA2, ELF-1, EPLG6, HEK7-L, LERK-6, LERK6, ephrin A2
External IDs	OMIM: 602756; MGI: 102707; HomoloGene: 1075; GeneCards: EFNA2; OMA:EFNA2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,301,431 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,025,844 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of sigmoid colon; ; buccal mucosa cell; ; mucosa of transverse colon; ; pancreatic ductal cell; ; jejunal mucosa; ; gonad; ; duodenum; ; right lobe of liver; ; sural nerve;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; Rostral migratory stream; ; abdominal wall; ; gastrula; ; limb bud; ; Gonadal ridge; ; fossa; ; condyle; ; ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ephrin receptor binding; protein binding;
Cellular component	anchored component of membrane; neuromuscular junction; perikaryon; membrane; plasma membrane;
Biological process	cell-cell signaling; olfactory bulb development; axon guidance; osteoclast differentiation; bone remodeling; ephrin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1943
	13637
	ENSG00000099617
	ENSMUSG00000003070
	O43921
	P52801
	NM_001405
	NM_007909
	NP_001396
	NP_031935
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene.

This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.