Ephrin A3

EFNA3
Identifiers
Aliases	EFNA3, EFL2, EPLG3, Ehk1-L, LERK3, ephrin A3
External IDs	OMIM: 601381; MGI: 106644; HomoloGene: 3635; GeneCards: EFNA3; OMA:EFNA3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,087,538 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,322,965 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; skin of arm; ; hair follicle; ; Region I of hippocampus proper; ; cervix epithelium; ; orbitofrontal cortex; ; prefrontal cortex; ; parotid gland; ; nucleus accumbens;
	Top expressed in
	lip; ; perirhinal cortex; ; entorhinal cortex; ; chorion; ; nasal epithelium; ; olfactory epithelium; ; subiculum; ; skin of external ear; ; dentate gyrus of hippocampal formation granule cell; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane-ephrin receptor activity; protein binding; ephrin receptor binding;
Cellular component	anchored component of membrane; plasma membrane; integral component of plasma membrane; membrane; intrinsic component of plasma membrane;
Biological process	cell-cell signaling; ephrin receptor signaling pathway; axon guidance; negative regulation of angiogenesis; regulation of neuron differentiation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1944
	13638
	ENSG00000143590
	ENSMUSG00000028039
	P52797
	O08545
	NM_004952
	NM_010108
	NP_004943
NP_034238; NP_001364045; NP_001364046; NP_001364047; NP_001364048;
	NP_001364049; NP_001364050
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin A3 is a protein that in humans is encoded by the EFNA3 gene.

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin.