Pikachurin

EGFLAM
Identifiers
Aliases	EGFLAM, AGRINL, AGRNL, PIKA, EGF like, fibronectin type III and laminin G domains, Smp_128580.1
External IDs	OMIM: 617683; MGI: 2146149; HomoloGene: 65044; GeneCards: EGFLAM; OMA:EGFLAM - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	38,465,480 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	7,427,876 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; tibialis anterior muscle; ; deltoid muscle; ; vastus lateralis muscle; ; tibial nerve; ; apex of heart; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; gonad;
	Top expressed in
	neural layer of retina; ; efferent ductule; ; spermatocyte; ; interventricular septum; ; spermatid; ; medial head of gastrocnemius muscle; ; left lung lobe; ; lumbar spinal ganglion; ; Gonadal ridge; ; vastus lateralis muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	glycosaminoglycan binding; calcium ion binding;
Cellular component	extracellular region; basement membrane; cell junction; interstitial matrix; synapse; extracellular matrix;
Biological process	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; extracellular matrix organization; positive regulation of cell-substrate adhesion; animal organ morphogenesis; tissue development; cell migration; substrate adhesion-dependent cell spreading;
	Sources:Amigo / QuickGO
Orthologs
	133584
	268780
	ENSG00000164318
	ENSMUSG00000042961
	Q63HQ2
	Q4VBE4
	NM_182801; NM_001205301; NM_152403; NM_182798; NM_182799
	NM_001289496; NM_001289498; NM_178748
	NP_001192230; NP_689616; NP_877950; NP_877953
	NP_001276425; NP_001276427; NP_848863
	Wikidata
View/Edit Human	View/Edit Mouse

Pikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that in humans is encoded by the EGFLAM gene.

Pikachurin is a dystroglycan-interacting protein which has an essential role in the precise interactions between the photoreceptor ribbon synapse and the bipolar dendrites. The binding with dystroglycan (DG) depends on several factors (glycosylation of DG, presence of divalent cations, presence of other proteins).

A non-correct binding between pikachurin and DG is associated with muscular dystrophies that often involve eye abnormalities.