EGLN3

EGLN3
Identifiers
Aliases	EGLN3, HIFP4H3, HIFPH3, PHD3, egl-9 family hypoxia inducible factor 3
External IDs	OMIM: 606426; MGI: 1932288; HomoloGene: 32531; GeneCards: EGLN3; OMA:EGLN3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	34,462,774 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	54,250,646 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; apex of heart; ; left ventricle; ; right auricle of heart; ; ventricular zone; ; right uterine tube; ; rectum; ; C1 segment; ; Amygdala;
	Top expressed in
	temporal muscle; ; masseter muscle; ; esophagus; ; mucous cell of stomach; ; conjunctival fornix; ; digastric muscle; ; epithelium of small intestine; ; epithelium of stomach; ; pyloric antrum; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	2-oxoglutarate-dependent dioxygenase activity; iron ion binding; L-ascorbic acid binding; dioxygenase activity; metal ion binding; protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; peptidyl-proline 4-dioxygenase activity;
Cellular component	nucleoplasm; nucleus; cytoplasm; cytosol;
Biological process	response to hypoxia; regulation of neuron apoptotic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; cellular response to DNA damage stimulus; regulation of cell population proliferation; regulation of transcription from RNA polymerase II promoter in response to hypoxia; activation of cysteine-type endopeptidase activity involved in apoptotic process; protein hydroxylation; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	112399
	112407
	ENSG00000129521
	ENSMUSG00000035105
	Q9H6Z9
	Q91UZ4
	NM_001308103; NM_022073
	NM_028133
	NP_001295032; NP_071356
	NP_082409
	Wikidata
View/Edit Human	View/Edit Mouse

Egl nine homolog 3 is a protein that in humans is encoded by the EGLN3 gene. ELGN3 is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem iron-containing proteins.