EIF1

EIF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IF1, 4KZX, 4KZY
Identifiers
Aliases	EIF1, A121, EIF-1, ISO1, SUI1, eukaryotic translation initiation factor 1, Eukaryotic initiation factor 1
External IDs	MGI: 105125; HomoloGene: 130538; GeneCards: EIF1; OMA:EIF1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,692,668 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,212,922 bp
RNA expression pattern
	Top expressed in
	sperm; ; oocyte; ; parotid gland; ; parietal pleura; ; tail of epididymis; ; lower lobe of lung; ; secondary oocyte; ; vena cava; ; caput epididymis; ; visceral pleura;
	Top expressed in
	granulocyte; ; muscle of thigh; ; morula; ; blastocyst; ; superior frontal gyrus; ; right kidney; ; ventricular zone; ; neural tube; ; extensor digitorum longus muscle; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation factor activity, RNA binding; translation initiation factor activity; RNA binding; protein binding; ribosomal small subunit binding;
Cellular component	cytoplasm; nucleus; eukaryotic 43S preinitiation complex;
Biological process	translational initiation; response to stress; dosage compensation by inactivation of X chromosome; protein biosynthesis; regulation of translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	10209
	20918
	ENSG00000173812
	ENSMUSG00000035530
	P41567
	P48024
	NM_005801
	NM_011508
	NP_005792
	NP_035638
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1.

eIF1 interacts with the eukaryotic small (40S) ribosomal subunit and eIF3, and is a component of the 43S preinitiation complex (PIC). eIF1 and eIF1A bind cooperatively to the 40S to stabilize an "open" conformation of the preinitiation complex (PIC) during eukaryotic translation initiation. eIF1 binds to a region near the ribosomal P-site in the 40S subunit and functions in a manner similar to the structurally related bacterial counterpart IF3.