EIF2AK1

EIF2AK1
Identifiers
Aliases	EIF2AK1, HCR, HRI, eukaryotic translation initiation factor 2 alpha kinase 1, LEMSPAD, hHRI
External IDs	OMIM: 613635; MGI: 1353448; HomoloGene: 8290; GeneCards: EIF2AK1; OMA:EIF2AK1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	6,059,175 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	143,841,069 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; monocyte; ; parotid gland; ; islet of Langerhans; ; ventricular zone; ; bone marrow; ; mucosa of ileum; ; bone marrow cells; ; stromal cell of endometrium; ; rectum;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; secondary oocyte; ; tibiofemoral joint; ; maxillary prominence; ; mandibular prominence; ; bone marrow; ; primary oocyte; ; right kidney; ; tail of embryo; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; ATP binding; heme binding; protein homodimerization activity; eukaryotic translation initiation factor 2alpha kinase activity; translation initiation factor activity;
Cellular component	cytoplasm;
Biological process	negative regulation of translation; phosphorylation; regulation of hemoglobin biosynthetic process; iron ion homeostasis; macrophage differentiation; protein phosphorylation; regulation of translational initiation by eIF2 alpha phosphorylation; acute inflammatory response; protoporphyrinogen IX metabolic process; regulation of eIF2 alpha phosphorylation by heme; phagocytosis; negative regulation of translational initiation by iron; regulation of translation; negative regulation of cell population proliferation; protein autophosphorylation; negative regulation of hemoglobin biosynthetic process; response to iron ion starvation; translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	27102
	15467
	ENSG00000086232
	ENSMUSG00000029613
	Q9BQI3
	Q9Z2R9
	NM_014413; NM_001134335
	NM_013557
	NP_001127807; NP_055228; NP_055228.2
	NP_038585
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene.