EIF4EBP1

EIF4EBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EJ4, 1WKW, 2JGB, 2JGC, 2V8W, 2V8X, 2V8Y, 3HXG, 3HXI, 3M93, 3M94, 3U7X, 4UED, 5BXV
Identifiers
Aliases	EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 1
External IDs	OMIM: 602223; MGI: 103267; HomoloGene: 3021; GeneCards: EIF4EBP1; OMA:EIF4EBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	38,060,365 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	27,766,702 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; parotid gland; ; muscle of thigh; ; gastrocnemius muscle; ; apex of heart; ; minor salivary glands; ; olfactory zone of nasal mucosa; ; right lobe of liver; ; stromal cell of endometrium; ; cartilage tissue;
	Top expressed in
	parotid gland; ; endothelial cell of lymphatic vessel; ; lacrimal gland; ; white adipose tissue; ; brown adipose tissue; ; muscle of thigh; ; embryo; ; granulocyte; ; gastrula; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	translation repressor activity; protein binding; eukaryotic initiation factor 4E binding; translation initiation factor binding; protein phosphatase 2A binding;
Cellular component	cytosol; cytoplasm; nucleus; protein-containing complex; glutamatergic synapse; postsynaptic cytosol;
Biological process	negative regulation of translation; negative regulation of translational initiation; positive regulation of mitotic cell cycle; TOR signaling; IRES-dependent translational initiation of linear mRNA; regulation of translation; insulin receptor signaling pathway; cellular response to dexamethasone stimulus; G1/S transition of mitotic cell cycle; response to ischemia; lung development; negative regulation of protein-containing complex assembly; response to ethanol; cellular response to hypoxia; response to amino acid starvation;
	Sources:Amigo / QuickGO
Orthologs
	1978
	13685
	ENSG00000187840
	ENSMUSG00000031490
	Q13541
	Q60876
	NM_004095
	NM_007918
	NP_004086
	NP_031944
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) is a protein that in humans is encoded by the EIF4EBP1 gene. inhibits cap-dependent translation by binding to translation initiation factor eIF4E. Phosphorylation of 4E-BP1 results in its release from eIF4E, thereby allows cap-dependent translation to continue thereby increasing the rate of protein synthesis.