EIF4ENIF1

EIF4ENIF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5ANR
Identifiers
Aliases	EIF4ENIF1, 4E-T, Clast4, eukaryotic translation initiation factor 4E nuclear import factor 1
External IDs	OMIM: 607445; MGI: 1921453; HomoloGene: 10522; GeneCards: EIF4ENIF1; OMA:EIF4ENIF1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,496,108 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,194,588 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; left testis; ; right testis; ; sural nerve; ; sperm; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; cerebellar vermis; ; ventricular zone;
	Top expressed in
	zygote; ; genital tubercle; ; tail of embryo; ; secondary oocyte; ; primary oocyte; ; Rostral migratory stream; ; interventricular septum; ; thymus; ; neural layer of retina; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; mRNA binding; RNA binding; nuclear export signal receptor activity;
Cellular component	cytoplasm; cytosol; PML body; nuclear speck; P-body; membrane; intracellular membrane-bounded organelle; nucleus;
Biological process	protein transport; stem cell population maintenance; negative regulation of translation; negative regulation of neuron differentiation; transport; nuclear export;
	Sources:Amigo / QuickGO
Orthologs
	56478
	74203
	ENSG00000184708
	ENSMUSG00000020454
	Q9NRA8
	Q9EST3
	NM_001164501; NM_001164502; NM_019843
	NM_001166547; NM_001166548; NM_001166549; NM_023743
	NP_001157973; NP_001157974; NP_062817
	NP_001160019; NP_001160020; NP_001160021; NP_076232
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene.

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.