EIF5A

EIF5A
Available structures
PDB	Ortholog search: I3L397 PDBe I3L397 RCSB
List of PDB id codes
	3CPF, 5DLQ
Identifiers
Aliases	EIF5A, EIF-5A, EIF5A1, eIF5AI, eukaryotic translation initiation factor 5A, eIF-4D, FABAS
External IDs	OMIM: 600187; MGI: 106248; HomoloGene: 133803; GeneCards: EIF5A; OMA:EIF5A - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,312,463 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,812,784 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; stromal cell of endometrium; ; mucosa of transverse colon; ; right testis; ; appendix; ; left testis; ; gastrocnemius muscle; ; islet of Langerhans; ; right adrenal gland;
	Top expressed in
	somite; ; primitive streak; ; hand; ; mandibular prominence; ; dermis; ; maxillary prominence; ; human fetus; ; abdominal wall; ; Gonadal ridge; ; migratory enteric neural crest cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; ribosome binding; translation elongation factor activity; protein binding; RNA binding; U6 snRNA binding;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; nuclear pore; lamellae anulatae; endoplasmic reticulum; extracellular exosome; nucleus; dendrite; soma;
Biological process	mRNA transport; protein biosynthesis; positive regulation of translational elongation; translational elongation; mRNA export from nucleus; peptidyl-lysine modification to peptidyl-hypusine; nucleocytoplasmic transport; protein export from nucleus; positive regulation of cell population proliferation; protein transport; translational frameshifting; positive regulation of translational termination; apoptotic process; positive regulation of cytosolic calcium ion concentration; ageing; positive regulation of cardiac muscle cell apoptotic process; positive regulation of apoptotic process; negative regulation of apoptotic process; positive regulation of muscle cell differentiation; cellular response to thyroid hormone stimulus; positive regulation of reactive oxygen species metabolic process; transport;
	Sources:Amigo / QuickGO
Orthologs
	1984
	276770
	ENSG00000132507; ENSG00000288145
	ENSMUSG00000078812
	P63241
	P63242
NM_001143760; NM_001143761; NM_001143762; NM_001970; NM_001370420;
	NM_001370421
NM_001166589; NM_001166590; NM_001166591; NM_001166592; NM_001166593;
	NM_001166594; NM_001166595; NM_001166596; NM_181582
NP_001137232; NP_001137233; NP_001137234; NP_001961; NP_001357349;
	NP_001357350
NP_001160061; NP_001160062; NP_001160063; NP_001160064; NP_001160065;
	NP_001160066; NP_001160067; NP_001160068; NP_853613
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene.

It is the only known protein to contain the unusual amino acid hypusine [N^ε-(4-amino-2-hydroxybutyl)-lysine], which is synthesized on eIF5A at a specific lysine residue from the polyamine spermidine by two catalytic steps.

EF-P is the bacterial homolog of eIF5A, which is modified post-translationally in a similar but distinct way. Both proteins are believed to catalyze peptide bond formation and help resolve ribosomal stalls, making them elongation factors despite the "initiation factor" name originally assigned.