EIF6

EIF6
Identifiers
Aliases	EIF6, CAB, EIF3A, ITGB4BP, b(2)gcn, eIF-6, p27(BBP), p27BBP, eukaryotic translation initiation factor 6
External IDs	OMIM: 602912; MGI: 1196288; HomoloGene: 7135; GeneCards: EIF6; OMA:EIF6 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,284,985 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,668,845 bp
RNA expression pattern
	Top expressed in
	mucosa of esophagus; ; mucosa of transverse colon; ; skin of leg; ; skin of abdomen; ; duodenum; ; rectum; ; vagina; ; human kidney; ; smooth muscle tissue; ; right lobe of liver;
	Top expressed in
	epiblast; ; primitive streak; ; morula; ; morula; ; endothelial cell of lymphatic vessel; ; esophagus; ; duodenum; ; jejunum; ; lip; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ribosome binding; protein binding; translation initiation factor activity; ribosomal large subunit binding;
Cellular component	cytoplasm; extracellular exosome; nucleus; nucleoplasm; nucleolus; cytosol; preribosome, large subunit precursor; lamin filament; intermediate filament;
Biological process	translational initiation; mature ribosome assembly; protein biosynthesis; ribosome biogenesis; response to insulin; maturation of LSU-rRNA; gene silencing by miRNA; regulation of glycolytic process; assembly of large subunit precursor of preribosome; maturation of 5.8S rRNA; regulation of fatty acid biosynthetic process; regulation of reactive oxygen species metabolic process; positive regulation of translation; regulation of megakaryocyte differentiation; miRNA-mediated gene silencing by inhibition of translation; ribosomal subunit export from nucleus; ribosomal large subunit biogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3692
	16418
	ENSG00000242372
	ENSMUSG00000027613
	P56537
	O55135
NM_001267810; NM_002212; NM_181466; NM_181467; NM_181468;
	NM_181469
	NM_010579
	NP_001254739; NP_002203; NP_852131; NP_852133
	NP_034709
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene.

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and catalyzes the association of the 40S and 60S ribosomal subunits along with eIF5 bound to GTP. Multiple transcript variants encoding several different isoforms have been found for this gene.

EIF6 plays important roles in Eukaryotic 80S ribosome formation, cell growth and gene expression. The 80S ribosome, which can separate into 40S and 60S subunits. EIF6 helps to protect mature 60S subunit and then EIF6 should disassociate with 60S subunit so that it can binds to 40S subunit to form ribosome. Keeping in balance of EIF6 is essential for the body: few EIF6 helps synthesis of normal ribosome, while large amount of EIF6 inhibited 60S subunits bind to 40S subunits.